蜂屋祐香君が中心となって行った担持Au触媒を用いたアリルエステルのアリル位ボリル化に関する研究成果がACS Catalysis 誌 (ACS)にAcceptされました。Our paper reporting efficient and versatile sp3 C-O bond borylation with a Au/TiO2 catalyst was accepted in ACS Catalysis (ACS).

₂ catalyst was accepted in ACS Catalysis (ACS).

「Practical Synthesis of Allyl, Allenyl and Benzyl Boronates through SN1'-Type Borylation under Heterogeneous Gold Catalysis」

Miura, Hiroki; Hachiya Yuka; Nishio, Hidenori; Fukuta, Yohei; Toyomasu, Tomoya; Kobayashi, Kosa, Masaki; Shishido, Tetsuya

ACS Catalysis, 2021, 11, 758-766. DOI: 10.1021/acscatal.0c03771

₂ showed high activity under mild conditions employing low catalyst loading conditions without the aid of any additives, such as phosphine and bases. A variety of allyl, propargyl and benzyl substrates participated in the heterogeneously catalyzed reactions to furnish the corresponding allyl, allenyl and benzyl boronates in high yields. Besides, the Au/TiO₂ was also effective for the direct borylation of allylic and benzylic alcohols. A mechanistic investigation based on a Hammett study and control experiments revealed that sp³

_N1'-type mechanism involving the formation of a carbocationic intermediate. The high activity, reusability and environmental compatibility of the supported Au catalysts as well as the scalability of the reaction system enable the practical synthesis of valuable organoboron compounds.