木村悠倫子君、寺島幸恵君が中心となって行った芳香族アミドとイミンの[3+2]付加環化反応に関する研究成果がEuropean Journal of Organic Chemistry誌(Wiley-VCH)にAcceptされました。Our paper reporting the coupling of aryl amides with aldimines catalyzed by Ru catalysts was published in Eur. J. Org. Chem..

本論文は、「Very Important Paper」に選出されました。This article is rated as "Very Important"

「Ruthenium-Catalyzed Synthesis of Isoindolinones via Amide-Directed Addition of Aromatic C-H Bonds to Aldimines」Miura, Hiroki; Kimura; YurikoTerashima, Sachie; Shishido, Tetsuya

European Journal of Organic Chemistry, 2019, , DOI: 10.1002/ejoc.201801755

Ruthenium-catalyzed addition of aromatic C-H bond toaldimines is described. [RuCl2(p-cymene)]2 functions as an efficientcatalyst to promote the coupling of aryl amides with aldimines in the presence of a catalytic amount of base to give the corresponding isoindolinone derivatives. Substituents of the N-atom of amides playa crucial role for efficient conversion of the substrates, and a ptoluenesulfonylgroup is the functionality of choice. A variety of amidesand aldimines participated in the present Ru-catalyzed reaction tofurnish the corresponding isoindolinones in good to high yield.