土井雅文君が中心となって行った担持金触媒によるC(sp3)-O結合のボリル化反応に関する研究成果がOrganic Letters誌 (ACS)にAcceptされました。Our paper reports the borylation of stable C(sp3)–O bonds of alkyl esters over supported Au catalysts in Organic Letters (ACS).

土井雅文君が中心となって行った担持金触媒によるC(sp3)-O結合のボリル化反応に関する研究成果がOrganic Letters誌 (ACS)にAcceptされました。Our paper reports the borylation of stable C(sp3)–O bonds of alkyl esters over supported Au catalysts in Organic Letters (ACS).

 

「Borylation of Stable C(sp3)–O Bonds of Alkyl Esters over Supported Au Catalysts」

Doi, Masafumi; Miura, Hiroki; Shishido, Tetsuya

Organic Letters, 2024，215, 2902–2907. DOI: 10.1021/acs.orglett.4c00225

 

We report herein that supported gold catalysts efficiently promote the borylation of stable C(sp³)–O bonds of alkyl esters. The use of a disilane as an electron source and gold nanoparticles as a single-electron transfer catalyst is the key to generating alkyl radicals via the homolysis of stable C(sp³)–O bonds, thereby enabling cross-coupling between bis(pinacolato)diboron and linear and cyclic alkyl esters to afford the diverse alkyl boronates.