安井祐希君が中心となって行った金ナノ粒子と固体酸の協同触媒反応によるC(sp3)-O結合の脱酸素的シリル化反応に関する研究成果がACS Catalysis誌 (ACS)にAcceptされました。Our paper reporting deoxygenative silylation of C(sp3)–O bonds with hydrosilane by cooperative catalysis of gold nanoparticles and solid acids in ACS Catalysis (ACS).

安井祐希君が中心となって行った金ナノ粒子と固体酸の協同触媒反応によるC(sp3)-O結合の脱酸素的シリル化反応に関する研究成果がACS Catalysis誌 (ACS)にAcceptされました。Our paper reporting deoxygenative silylation of C(sp3)–O bonds with hydrosilane by cooperative catalysis of gold nanoparticles and solid acids in ACS Catalysis (ACS).

 

「Deoxygenative Silylation of C(sp3)–O Bonds with Hydrosilane by Cooperative Catalysis of Gold Nanoparticles and Solid Acids」.

Miura, Hiroki; Yasui, Yuki; Masaki, Yosuke; Doi, Masafumi; Shishido, Tetsuya

ACS Catalysis, 2023, 13, 6787−6794. DOI: 10.1021/acscatal.3c00973 [Highlighted in SYNFACTS]

 

Efficient deoxygenative silylation of C(sp3)–O bonds with hydrosilanes by supported Au catalysts is described. Gold
nanoparticles supported on TiO2 enabled various hydrosilanes to be used as sources of silyl groups in C–Si cross-coupling reactions. A variety of alkyl acetates and propargyl carbonates participated in the Au-catalyzed reactions to furnish the corresponding
alkyl and allenylsilanes in high yields. In addition, Au/TiO2 was also effective for ring-opening silylation of cyclic ethers. A detailed
mechanistic investigation corroborated that the title reaction involves the formation of silyl and alkyl radical intermediates and the
cooperation of Au nanoparticles as single-electron transfer catalysts and Lewis acid sites at the surface of metal oxides was responsible for the unusual reactivity of hydrosilanes for specific C(sp3)–Si bond formation.